cGMP EcoCRM^® and Research Grade EcoCRM^® Available

Carrier Proteins

Carrier proteins are used to convert polysaccharides from T-cell independent antigens, into T-cell dependent antigens by linking the two together.  They are also used to improve the immunogenicity of oligosaccharides, peptides and proteins.

CRM₁₉₇ Carrier Protein

CRM₁₉₇, a genetically detoxified diphtheria toxin, is widely used as a carrier protein in conjugate vaccines, including effective conjugate vaccines against Streptococcus pneumoniae, Haemophilus influenzae b and Neisseria meningitidis. Fina BioSolutions has developed a highly efficient E. coli expression system for CRM₁₉₇. We express soluble, properly folded CRM₁₉₇ in the cytoplasm of E.coli. High expression levels and a simple purification scheme allow us to produce CRM₁₉₇ at low cost and price it accordingly.

Fina Biosolutions is pleased to offer EcoCRM^®, economical CRM₁₉₇ from E. coli, to the research and vaccine manufacturing community.