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cGMP EcoCRM® and Research Grade EcoCRM® Available

Carrier Proteins

Carrier proteins are used to convert polysaccharides from T-cell independent antigens, into T-cell dependent antigens by linking the two together.  They are also used to improve the immunogenicity of oligosaccharides, peptides and proteins.

CRM197 Carrier Protein

CRM197, a genetically detoxified diphtheria toxin, is widely used as a carrier protein in conjugate vaccines, including effective conjugate vaccines against Streptococcus pneumoniae, Haemophilus influenzae b and Neisseria meningitidis. Fina BioSolutions has developed a highly efficient E. coli expression system for CRM197. We express soluble, properly folded CRM197 in the cytoplasm of E.coli. High expression levels and a simple purification scheme allow us to produce CRM197 at low cost and price it accordingly.

Fina Biosolutions is pleased to offer EcoCRM®, economical CRM197 from E. coli, to the research and vaccine manufacturing community.

Size Price
1 mg $250
5 mg $750
10 mg $1,250
25 mg $2,850
50 mg $5,250
GMP CRM197 Inquire

BIBLIOGRAPHY: NEW: Bibliography for EcoCRM®, FinaBio’s CRM197, as of May 31, 20211-15 Download Now

POSTER: NEW: Analytical Assessments of CRM197 Download Now

POSTER: NEW: EcoCRM – A Recombinant CRM197 Carrier Protein Download Now

POSTER: EcoCRM: Economical Recombinant CRM197 Download Now

POSTER: Biophysical Evaluation of EcoCRM Download Now

POSTER: EcoCRM: Affordable CRM197 Vaccine Carrier Protein Download Now

JOURNAL ARTICLE: Analytical Comparability Assessments of 5 Recombinant CRM197 Proteins From Different Manufacturers and Expression Systems Download Now

WHITE PAPER: CRM197 is Superior to KLH as a Carrier Protein Download Now

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EcoCRM (CRM197)


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